Manchester United boss David Moyes could still be searching for the right balance after Shakhtar Donetsk coach Mircea Lucescu suggested rotation should be blamed for United poor form.
They face Shakhtar in the Champions League on Wednesday after Saturday’s 2-1 defeat by West Brom signalled their worst league start in 24 years.
“We will be looking for a balance of experience and youth,” said Moyes, 50.
“We will be trying to introduce new young players at the right times but also rely a lot on the great experience many of the players have at Manchester United.”
United travel to the Donbass Arena after three defeats in their opening six Premier League games of the season as they make a fresh start following the retirement of Sir Alex Ferguson.
They began their Champions League campaign with a 4-2 defeat of Bayer Leverkusen, while their hosts on Wednesday beat Real Sociedad 2-0.
Shakhtar are third in the Ukrainian Premier League having secured three successive domestic doubles.