Atletico Madrid came up with four unreplied goals against Real Madrid to claim their fourth derby win of the season.
Tiago put the hosts in ascendancy with a right-footed shot, which Real goalkeeper Iker Cassillas fumbled with.
Substitute midfielder Saul Niguez doubled their advantage moments later via an incredible bicycle kick.
Antoine Griezeman put the game beyond the Los Blancos after the restart, when he poked home from close range.
Mario Mandzukic rounded off a memorable evening at the Vicente Calderon with a headed goal.
The result leaves Real with a four point lead over second-placed Barcelona, who make a short trip to Athletic Bilbao on Sunday.
The La Liga champions, who are now level on points with Barcelona, are unbeaten in six matches against Carlo Ancelotti’s men, with four wins and two draws so far this season.
An injury-depleted Real had Cristiano Ronaldo back from a two-match suspension but were without the injured quartet of James Rodriguez, Sergio Ramos, Luka Modric and Pepe.