Italy international, Claudio Marchisio is set to be sidelined for six to eight months with a serious right knee injury.
The 29-year-old suffered the injury during training session on Friday and, after subsequent scans; the Italian football federation (FIGC) have confirmed that he damaged his anterior cruciate ligament in his right knee.
A statement from the FIGC read: “During (Friday’s) warm-up, Marchisio sustained trauma in his right knee.
“An MRI scan was immediately carried out in Florence and it has revealed a subtotal lesion of the anterior cruciate ligament.
“After informing the Juventus medical staff, the player will return to his club.”
The Juventus midfielder will proceed to the surgical room, after which he is expected to be sidelined for not less than six months.
Italy face Bulgaria in Sofia on Saturday in an Euro 2016 qualifier before hosting England in an international friendly in Turin three days later.
The Bianconeri are 14 points clear of Roma at the summit of the Serie A with 10 games left. They are through to the quarter-finals of the Uefa Champions League and the last 4 of the Coppa Italia.
Marchisio has scored twice and assisted in five more goals in 27 league games this season.